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The Ancylostoma & Uncinaria (qPCR) product is used to detect sequences specific to selected hookworms of the genera Ancylostoma and Uncinaria in DNA preparations obtained from human feces.
Kit size: 100 reactions
Reaction_1: triplex (FAM: Ancylostoma caninum/duodenale/tubaeforme, HEX: internal control, Texas Red: Ancylostoma ceylanicum)
Reaction_2: triplex (FAM: AAncylostoma brasiliense, HEX: internal control, Texas Red: Uncinaria stenocephala)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Infections with dog hookworms of the genera Ancylostoma and Uncinaria (Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma caninum, and Uncinaria stenocephala) lead to symptoms and even death in dogs. In humans, infections with these pathogens cause tropical zoonoses (zoonotic diseases).
Each species of hookworm differs significantly in terms of geographical distribution, severity of symptoms caused, and potential to cause zoonoses. Dogs and humans become infected transdermally or orally by ingesting encysted larvae in soil or through contaminated food or water.
Infection, especially with A. caninum, is a common cause of hemorrhagic diarrhea and death in puppies and chronic iron deficiency anemia in adult animals. All species of dog hookworms cause cutaneous larva migrans (CLM). Among human infections, A. braziliense is by far the most common. In humans, A. caninum is a well-known cause of eosinophilic enteritis and aphthous ileitis. Although most infections are asymptomatic, a single immature adult worm inhabiting the small intestine can cause abdominal pain, intestinal bleeding, diarrhea, and weight loss.
In turn, A. ceylanicum is the only species of dog (and cat) hookworm that causes long-term infection in the human gastrointestinal tract, both in natural and experimental infections. In the Asia-Pacific region, A. ceylanicum is the second most common hookworm infecting humans after Necator americanus and accounts for 5.5–51.6% of human infections in Laos, Malaysia, Thailand, Cambodia, and the Solomon Islands.
