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The Aspergillus/Candida albicans (qPCR) product is used to detect sequences specific for Candida albicans and selected species of fungi from the genus Aspergillus in DNA preparations obtained from environmental samples and biological material collected from humans and animals.
Kit size: 100 reactions
Reaction: triplex (FAM: wybrane gatunki Aspergillus, Texas Red: Candida albicans, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
The yeast Candida albicans is the most important fungal pathogen in humans. Under normal circumstances, it is a benign colonizer of human mucosal surfaces and is therefore highly specialized to live on or in the human host. However, certain changes in the host environment can result in a transition from the commensal to the pathogenic phase, enabling infection of virtually any organ in the human body and causing severe infections. Even a slightly weakened immune system or a minor imbalance in the microbiome may be sufficient for C. albicans to cause infections of the skin or mucosal surfaces.
However, the severity of candidiasis increases dramatically in patient populations with predisposing factors. Such factors include severely compromised immunity (e.g., neutropenia) or cancer (e.g., leukemia). The development of infection is facilitated by disruption of natural barriers (e.g., by burns or disruption of the intestinal mucosal barrier by abdominal surgery), the presence of indwelling catheters, dialysis, or parenchymal organ transplantation.
Bloodstream infections caused by Candida albicans, mainly hospital-acquired (invasive infections), are life-threatening diseases. Candidemia is currently the third most common form of hospital-acquired bloodstream infections and accounts for 9% of all such infections. Even with rapid antifungal treatment, disseminated candidiasis has a mortality rate of up to 50%, depending on the underlying disease.
Aspergillus species play a role in three different clinical situations in humans: opportunistic infections, allergic conditions, and poisoning, with inhalation being the primary route of transmission of spores. Aspergillus species have been linked to a number of infections, collectively referred to as aspergillosis. The most common are allergic bronchopulmonary aspergillosis (ABPA), aspergilloma, chronic necrotizing aspergillosis (CNA), and invasive pulmonary aspergillosis (IPA). The disease usually affects the lungs and can also spread to other parts of the body.
Aspergillosis primarily affects people with existing medical conditions, especially those with damaged lungs and compromised immune systems. Typical symptoms associated with aspergillosis include difficulty breathing, increased thirst, diarrhea, and fever. The most significant species in the development of human disease are A. niger, A. flavus, A. fumigatus, A. versicolor, A. nidulans, and A. candidus.
