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The CHV (qPCR) product is used to detect sequences specific to canine herpesvirus (CHV) in DNA preparations obtained from biological material collected from dogs.
Kit size: 100 reactions
Reaction: duplex (FAM: CHV, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Canine herpesvirus (CHV) is also known in the literature as canine alphaherpesvirus 1 (CaHV-1) and canine herpesvirus 1 (CHV-1). As with all herpesviruses, the CaHV-1 genome consists of double-stranded, linear DNA approximately 125,000 base pairs (bp) in length. It contains 76 open reading frames for structural and functional gene products.
CaHV-1 belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. The host range of CaHV-1 is limited to domestic and wild canids. Serological studies have shown close antigenic relationships between CaHV-1, feline herpesvirus type 1 (FHV-1), and phocine herpesvirus type 1 (PhHV-1).
CaHV-1 is found worldwide, and its pathogenic potential has been linked to the age of infected animals. Adult dogs are susceptible to CHV-1, but the infection is usually asymptomatic, subclinical, or localized in the reproductive tract of the infected animal. However, primary infection or reactivation of latent infection in pregnant bitches can cause reproductive disorders, including infertility, abortion, resorption or mummification of the fetus, stillbirth, or perinatal infection, with systemic disease and death of newborns.
In puppies several weeks old, CaHV-1 infection causes a fatal hemorrhagic disease. Puppies become infected with the virus during birth in the birth canal or through contact with infected secretions from the mouth and nose of their mother or other infected dogs. Symptoms include crying, weakness, depression, nasal discharge, soft yellow stools, and loss of suckling reflex. The infection also causes necrotizing vasculitis, which causes hemorrhage around the blood vessels. The symptoms of the disease are accompanied by a high mortality rate, reaching 80 percent in puppies less than one week old.
