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The Dermatophytes (qPCR) product is used to detect sequences specific to fungi, such as dermatophytes in DNA preparations obtained from biological material collected from humans and animals.
Kit size: 100 reactions
Reaction: duplex (FAM: dermatophytes, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
The Dermatophytes (qPCR) product enables the detection of dermatophytes belonging to the genera Trichophyton, Epidermophyton, Microsporum, and Nannizzia.
Dermatophytes are the most common pathogenic filamentous fungi, with an infection rate of 20-25% worldwide. These fungi usually infect the nails, skin, and hair, causing many superficial dermatophytoses, such as scalp ringworm, nail fungus, body ringworm, and foot fungus. Less commonly, dermatophytes can also attack skin tissue and even deep organs, especially in immunocompromised patients with congenital or acquired immunodeficiency. These infections can lead to life-threatening conditions if not treated properly.
Dermatophytes can be divided into three types based on host preference and ecological niches. Anthropophilic dermatophytes are mainly transmitted from person to person and usually cause chronic infections with moderate clinical symptoms. Zoophilic dermatophytes prefer selective animal hosts but can usually infect other species, including humans, often causing inflammatory skin infections. Geophilic dermatophytes survive on keratinized debris present in the soil and are rarely pathogenic. However, they can sometimes cause more severe inflammation than anthropophilic species. One of the most commonly detected species worldwide is Trichophyton rubrum, which accounts for 50%–90% of dermatophytosis.
Based on phylogenetic studies of the Arthrodermataceae family, to which dermatophytes belong, seven monophyletic clades of dermatophytes representing the genera Trichophyton, Epidermophyton, Nannizzia, Microsporum, Lophophyton, Paraphyton, and Arthroderma have been identified. Infections in humans and animals are primarily caused by dermatophytes belonging to the first four clades.
Zoophilic dermatophytes that play an important role in veterinary medicine include the species Microsporum and Trichophyton, which cause skin diseases in companion animals, mainly dogs and cats. The most important species are T. mentagrophytes, T. benhemiae, and M. canis. Anthropophilic dermatophytes include T. rubrum, T. interdigitale, T. tonsurans, T. violaceum, M. audouinii, and E. floccosum. A geophilic species that rarely infects humans and animals is N. gybsea.
