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The Entamoeba histolytica, dispar (qPCR) product is used to detect sequences specific to the protozoa Entamoeba histolytica and Entamoeba dispar in DNA preparations obtained from feces.
Kit size: 100 reactions
Reaction: duplex (FAM: Entamoeba histolytica, HEX: internal control, Texas Red: Entamoeba dispar)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Among the protozoa inhabiting the human intestine, two species of the genus Entamoeba are of particular importance: Entamoeba histolytica and Entamoeba dispar. Both species can colonize the human digestive tract, but their impact on human health differs diametrically. Entamoeba histolytica is a pathogen that causes amoebiasis (amoebic dysentery). It is an infectious disease that can lead to serious complications, including liver abscesses and, in extreme cases, even death. It is estimated that up to 100,000 people die from it each year. This makes it the third most common parasitic cause of death worldwide.
In contrast, Entamoeba dispar is a non-pathogenic commensal that does not cause any symptoms and does not pose a health risk. Despite these significant differences, both species are morphologically almost identical. Thus, it is almost impossible to distinguish between them using traditional methods such as microscopic examination. This, in turn, leads to the risk of misdiagnosis and unnecessary treatment of people infected with E. dispar who do not require therapeutic intervention.
For this reason, molecular biology techniques, which allow for precise species differentiation, are becoming increasingly important in the diagnosis of Entamoeba infections. This approach is crucial, especially in endemic regions: Central and South America, Asia, and Africa. In these regions the prevalence of infections is high and access to modern diagnostics is often limited. Correct species identification is important not only for effective treatment, but also for epidemiological surveillance and limiting the spread of amoebiasis worldwide.
