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The FIV (qPCR) product is used to detect sequences specific to feline immunodeficiency provirus in DNA preparations obtained from biological material collected from cats.
Kit size: 100 reactions
Reaction: duplex (FAM: FIV, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Feline immunodeficiency virus (FIV) is a virus belonging to the retrovirus family, genus lentivirus. It causes immunodeficiency in domestic cats, which is referred to as immunodeficiency syndrome and commonly known as feline AIDS because it resembles the human form of the disease.
Feline immunodeficiency virus was first detected in domestic cats (Felis catus) with a history of chronic, recurrent, and opportunistic infections that resembled the immunodeficiency syndrome seen in humans infected with the human immunodeficiency virus (HIV). Feline immunodeficiency virus (FIVfca) causes a serious, lifelong infection.
Lentivirus infections have also been detected in several non-domestic cat species, including African lion populations (FIVple) in eastern and southern Africa, but there is significant sequence divergence between lentiviruses from different host species. In conserved regions of the polymerase (Pol) gene, nucleotide sequence differences are 30% and even greater in regions encoding the envelope glycoprotein and core protein.
Infected cats generally show no clinical signs for several years, and in some cats the disease never develops. Typical symptoms include chronic gingivitis and stomatitis, chronic rhinitis, enlarged lymph nodes, weight loss, and immune-mediated glomerulonephritis. Additional clinical signs are a consequence of the cat’s reduced immunity and increased susceptibility to secondary infections.
Feline immunodeficiency virus spreads during cat fights. For this reason, the disease is more common in young, intact cats that go outdoors. Infection can also occur during a blood transfusion if the blood has not been previously tested.
