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The Lyme Disease Borrelia (qPCR) product is used to detect sequences specific to bacteria of the genus Borrelia that cause Lyme disease in DNA preparations obtained from ticks and material collected from animals and humans.
Kit size: 100 reactions
Reaction: duplex (FAM: Lyme Disease Borrelia, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Borrelia species are divided into two main clades (groups), each of which is characterized by considerable heterogeneity. One clade includes spirochetes that cause relapsing fever. The other clade contains species that cause Lyme disease (Borrelia). Currently, this clade includes at least 20 proposed or confirmed species worldwide, of which nine have been found to cause disease in humans: B. burgdorferi, B. afzelii, B. garinii, B. bavariensis, B. spielmanii, B. lusitaniae, B. bissettii, B. valaisiana, and B. mayonii. Spirochetes from the Lyme Disease group Borrelia are transmitted by several species of hard ticks of the genus Ixodes.
Lyme disease is the most common tick-borne disease in the northern hemisphere. The primary stage of the disease is characterized by erythema migrans, a specific but not constant symptom. Patients in the later stages of the disease suffer from subjective or nonspecific polymorphic signs and symptoms that may persist after completion of currently recommended antibiotic treatments. In most cases, there is weakness, with pain that may be localized in the joints, muscles, bones, or have a neurological origin. The pain is often migratory. Many patients complain of neurocognitive disorders.
In late Lyme disease, inflammation most commonly affects the joints, but it can also involve the nervous system and, in Europe, the skin. Symptoms of late Lyme disease occur months or years after the tick bite. In some people, these symptoms may be the first signs of the disease. Muscle and joint symptoms are the most common symptoms of late-stage Lyme disease. They occur in 80 percent of people with Lyme disease who have not been treated with antibiotics.
Neuroborreliosis, on the other hand, can cause various neurological symptoms, including pain, difficulty with memory or thinking, and strange sensations such as numbness. Symptoms of skin borreliosis include skin nodules, swelling, and subsequent thinning of skin patches, which usually occur on the hands, feet, knees, or elbows.
