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The Mycoplasma haemofelis, haemominutum, turicensis (qPCR) product is used to detect sequences specific to the hemotropic mycoplasmas Mycoplasma haemofelis, Candidatus Mycoplasma haemominutum, and Candidatus Mycoplasma turicensis in DNA preparations obtained from cat blood.
Kit size: 100 reactions
Reaction: triplex (FAM: Mycoplasma haemofelis, Texas Red: Candidatus Mycoplasma haemominutum, Cy5: Candidatus Mycoplasma turicensis, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Cat hemoplasmas are the causative agents of infectious anemia in felines. Currently, at least three species of hemoplasmas have been described in cats: Mycoplasma haemofelis (M. haemofelis), Candidatus Mycoplasma haemominutum (Candidatus M. haemominutum), and Candidatus Mycoplasma turicensis (Candidatus M. turicensis). The pathogenic potential of different species of feline hemoplasmas varies. Some isolates consistently cause hemolytic anemia, while others cause few noticeable clinical signs.
Coexisting factors such as immunosuppression, co-infections with other species of hemoplasmas, or retroviral infections may lead to a more severe course of the disease. The age of the animal may also be relevant. It has been suggested that younger cats are more susceptible to clinical hemoplasmosis. Other factors influencing the course of the disease include the route of infection and the amount of bacteria that has entered the cat’s body.
Mycoplasma haemofelis causes hemotropic mycoplasmosis in cats, manifested by a decrease in erythrocyte and/or hemoglobin levels and the development of anemia. Anemia may be mild and cause no visible symptoms. Some cats with subclinical disease remain long-term carriers of the disease, infecting other cats. If another disease or condition lowers the cat’s immunity, the infection may cause more severe clinical symptoms.
Infection with Candidatus M. haemominutum rarely causes significant clinical signs, and anemia is not usually induced. However, a decrease in red blood cell parameters may occur. Significant anemia may occur following infection with Candidatus M. haemominutum in cats infected with retroviruses, particularly those infected with feline leukemia virus (FeLV), in which Candidatus M. haemominutum may also play a role in causing bone marrow disorders.
Candidatus M. turicensis was first described in naturally infected cats with severe hemolytic anemia. Further studies have confirmed its occurrence worldwide in wild and domestic cats. The pathogenic potential of Candidatus M. turicensis appears to vary. Some infections cause hemolytic anemia, while others cause few clinical signs. A significant number of cats infected with Candidatus M. turicensis have coexisting diseases such as cancer or feline immunodeficiency virus (FIV) infection. It suggests that coexisting factors and immunosuppression may be important in the pathogenesis of disease caused by this species of hemoplasma.
