Log in to see the prices.
The price above is a net price.
The Neisseria miningitidis serotypes B, C, W, Y (qPCR) product is used to determine sequences specific to serotypes B, C, W, Y of Neisseria miningitidis bacteria causing CNS (central nervous system) diseases in DNA preparations obtained from cultures on Petri dishes.
Kit size: 100 markers
Reaction: fourplex (FAM: serotype B Neisseria miningitidis, HEX:serotyp C Neisseria miningitidis, Texas Red: serotype W Neisseria miningitidis, Cy5: serotype Y Neisseria miningitidis)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Neisseria meningitidis is a Gram-negative bacterium commonly known as meningococcus. It can cause meningitis and other forms of meningococcal disease, such as meningococcemia, a life-threatening form of sepsis. Neisseria meningitidis causes significant morbidity and mortality among children and young adults worldwide as a result of epidemics or sporadic meningitis and/or sepsis.
Neisseria meningitidis causes significant morbidity and mortality among children and young adults worldwide as a result of epidemics or sporadic meningitis and/or sepsis. Meningococcal infection is a global but heterogeneous problem occurring as sporadic, hypersporadic, and epidemic disease. It is estimated that there are 1.2 million cases of meningococcal disease annually, with approximately 135,000 deaths worldwide. Disease patterns vary considerably over time and between geographic areas, age groups, and bacterial serogroups.
The pathogen is usually transmitted through saliva during intimate contact, such as sharing a drink or kissing. The reservoir of infection may be another infected person or a carrier. The main source of infection are asymptomatic carriers. They constitute 5–10% of the population in non-epidemic periods and about 50% during epidemics. In closed populations, the percentage of carriers can reach up to 80%.
Meningococci are classified according to serological typing, and the traditional approach is serogrouping. Further classification into serological subtypes, serotypes, and immunotypes is respectively based on the structure of PorA, PorB, and LOS. Based on their immunological reactivity and capsular polysaccharide structure, 13 distinct groups of meningococci have been defined. These serogroups are: A, B, C, E-29, H, I, K, L, W-135, X, Y, Z, and Z’ (29E). Only six serogroups (A, B, C, W-135, X, Y) cause life-threatening diseases. Serogroup identification is performed by slide agglutination or PCR, while other types of meningococci are identified by monoclonal antibodies (mAb), PCR, and DNA sequencing.
