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The Pathogenic Leptospira spp. (qPCR) product is used to detect sequences specific to pathogenic species of the Leptospira genus in DNA preparations obtained from the blood and urine of infected animals and humans.
Kit size: 100 reactions
Reaction: duplex (FAM: Pathogenic Leptospira spp., HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Leptospira is a genus of Gram-negative bacteria belonging to the spirochete type. Within this genus, there are pathogenic, saprophytic, and intermediate species, which have characteristics of both pathogenic and saprophytic species. Infections with pathogenic species cause diseases collectively referred to as leptospirosis. Animals and humans around the world suffer from leptospirosis. A higher incidence of the disease is observed in countries with warm climates and in large-scale animal breeding operations. The disease is more common during the warm season.
The main species of animals of economic importance affected by leptospirosis are cattle, goats, sheep, horses, and fur animals (arctic foxes and silver foxes). The course of the disease depends on the species and age of the animal. The acute form of the disease is mainly observed in young animals. In calves, young goats, and sheep, typical symptoms include fever, loss of appetite, conjunctivitis, diarrhea, sometimes jaundice, hemoglobinuria, anemia, pneumonia, meningitis accompanied by impaired coordination, salivation, and muscle stiffness. Up to 10% of infections can result in the death of the animal.
Dogs are domestic animals that can contract leptospirosis. The course and symptoms of the disease vary and depend on the serovar/strain of Leptospira, the age and sex of the animal, and the state of its immune system. The disease usually begins with fever, chills, depression, loss of appetite, muscle pain, weakness, and stiff gait. Over time, symptoms of kidney involvement may appear.
Leptospirosis is also one of the most common zoonotic diseases in humans, with approximately 500,000 cases reported annually. The disease is usually transmitted to humans through contact with water contaminated with the urine of animal reservoirs. Leptospires enter through broken skin or mucous membranes and spread throughout the body. Infections in the early stages of the disease are similar to flu-like illnesses and can lead to severe symptoms such as Weil’s disease and severe pulmonary hemorrhage syndrome, for which the mortality rate is over 10%.
