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The Schistosoma mansoni (qPCR) product is used to detect sequences specific to the Schistosoma mansoni fluke in DNA preparations obtained from human blood and feces.
Kit size: 100 reactions
Reaction: duplex (FAM: Schistosoma mansoni, HEX: internal control)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
Schistosoma mansoni is a species of flatworm whose definitive host is usually humans. It causes a disease called schistosomiasis. The adult form of the flatworm lives in blood vessels and feeds on blood. The intermediate hosts of blood flukes are freshwater snails, mainly from the Bulinidae family. In addition to humans, the final hosts of this species of fluke can be animals such as rodents, opossums, and some species of monkeys (guenons and baboons).
Schistosoma mansoni is one of three main species of schistosomes that infect humans. The other two species are Schistosoma haematobium and Schistosoma japonicum. All three species are found in different (sub)tropical areas. S. mansoni is common in many countries in Africa, parts of the Middle East, South America, and the Caribbean. S. haematobium is found in parts of Africa and the Middle East. Schistosoma japonicum is found in China, Indonesia, and the Philippines. Other human species are found in a more limited range in the Democratic Republic of Congo (S. intercalatum), Central Africa (S. guineensis), and Laos and Cambodia.
S. mansoni eggs induce inflammation of the colon mucosa. This results in ulcers and papillomas, as well as cancerous lesions. S. mansoni eggs can travel with the blood to other organs, such as the liver, lungs, brain, and even the eyes. In the liver, the eggs can block the lumen of the veins, leading to enlargement of this organ and also of the spleen. In addition, edema, ascites, and jaundice may occur.
