Log in to see the prices.
The price above is a net price.
The Streptococcus pneumoniae/Neisseria meningitidis/Haemophilus influenzae (qPCR) product is used to detect sequences specific to Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae bacteria causing CNS (central nervous system) diseases in DNA preparations obtained from human material.
Kit size: 100 markers
Reaction: fourplex (FAM: Streptococcus pneumoniae, HEX: internal control, Texas Red: Neisseria meningitidis, Cy5: Haemophilus influenzae)
Internal control: exogenous/endogenous
Determination: qualitative/quantitative
Kit components:
CNS (central nervous system) diseases caused by bacterial infections can lead to serious disorders in the functioning of the body. The most common are bacterial meningitis and encephalitis, which can be caused by bacteria such as Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. The symptoms of such infections often develop rapidly and may include fever, severe headache, neck stiffness, impaired consciousness, and seizures. Untreated infections can lead to permanent neurological damage or even be life-threatening, which is why rapid diagnosis and early antibiotic treatment are crucial. Thanks to vaccinations and modern treatment methods, the risk of serious complications can be significantly reduced.
Streptococcus pneumoniae is a commensal bacterium of the human upper respiratory tract and an important pathogen causing a range of bacterial diseases. The spectrum of diseases ranges from mild and common childhood respiratory tract infections, such as otitis media, to potentially fatal pneumococcal diseases, such as pneumonia or meningitis.
S. pneumoniae is the most common pathogen causing community-acquired pneumonia. It is estimated that pneumococcal pneumonia caused 1.5 million deaths worldwide in 2015, including approximately 400,000 deaths in children under 5 years of age. Other infections, particularly pneumococcal bacteremia and meningitis, although less common, cause high mortality and long-term neurological sequelae in survivors. The case fatality rate for pneumococcal meningitis was 25–27% in Europe and the Americas in 2015, and as high as 61% in Africa.
Neisseria meningitidis is a Gram-negative bacterium commonly known as meningococcus. It can cause meningitis and other forms of meningococcal disease, such as meningococcemia, a life-threatening form of sepsis. Neisseria meningitidis causes significant morbidity and mortality among children and young adults worldwide as a result of epidemics or sporadic meningitis and/or sepsis.
Meningococcal infection is a global but heterogeneous problem occurring as sporadic, hypersporadic, and epidemic disease. It is estimated that there are 1.2 million cases of meningococcal infection annually, with approximately 135,000 deaths worldwide. Disease patterns vary significantly over time and between geographic areas, age groups, and bacterial serogroups.
Haemophilus influenzae is a bacterium restricted to humans, colonizing the nasopharynx and, to a lesser extent, the conjunctiva and genital tract. The bacterium has been differentiated into six capsular types (a to f) according to the polysaccharide structure of the capsule. Other strains do not have a capsule and are classified as non-capsulated or non-typable H. influenzae (NTHi). The most virulent serotype is H. influenzae type b (Hib), and its capsule, composed of polyribosylribitol phosphate (PRP), is the dominant virulence factor.
Haemophilus influenzae has historically been the main cause of bacterial meningitis and other invasive diseases in children. This pathogen causes various conditions, ranging from relatively mild otitis media to severe diseases such as sepsis. There are two types of infections caused by H. influenzae: invasive and non-invasive. Invasive Hib infection is common in children under 5 years of age and mainly includes pneumonia and meningitis. NTHi strains are responsible for invasive infections such as bacteremia without an identifiable focus, bacteremic pneumonia, and meningitis.
The Streptococcus pneumoniae/Neisseria meningitidis/Haemophilus influenzae (qPCR) product allows for the detection of DNA sequences specific to three groups of pathogens that cause a number of diseases, including diseases of the central nervous system (CNS):
The DNA sequences of the above pathogens can be determined qualitatively. They are determined in a fourplex reaction. A fragment of the human genome serves as an internal control. This allows the product to monitor the quality of the biological material used for DNA extraction and the correct course of the DNA extraction process.
